Evaluation of an injectable, photopolymerizable three- dimensional scaffold based on D,L-lactide and s-caprolactone in a tibial goat model

摘要

An in situ crosslinkable, biodegradable, meth-acrylate-encapped porous bone scaffold composed of D,L-lactide, e-caprolactone, 1,6-hexanediol and poly(ortho-esters), in which crosslinkage is achieved by photoiniti-ators, was developed for bone tissue regeneration. Three different polymer mixtures (pure polymer and 30% bio-active glass or α-tricalcium phosphate added) were tested in a uni-cortical tibial defect model in eight goats. The polymers were randomly applicated in one of four (6.0 mm diameter) defects leaving a fourth defect unfilled. Bio-compatibility and bone healing properties were evaluated by serial radiographies, histology and histomorphometry. The pure polymer clearly showed excellent biocompati-bility and moderate osteoconductive properties. The addition of α-TCP increased the latter characteristics. This product offers potentials as a carrier for bone healing promoter substances.