APPLICATION OF HPLC METHOD FOR INVESTIGATION OF STABILITY OF NEW BENZIMIDAZOLE DERIVATIVES

摘要

Obtained benzimidazole derivatives, our newly synthesized heterocyclic compounds, belong to a new group of chemical bondings with potential anticancer features. A biochemical study determining anticancer activity of benzimidazole derivatives was conducted in the environment of 0.2% DMSO (dimethyl sulfoxide). The HPLC method was used to determine stability of these compounds in a biochemical study environment. Optimization of the chromatographic system and validation of the established analytical method were performed. Stability analysis of the derivatives was examined in the reversed phases RP-8 system, where pure acetonitrile was used as an eluent for the analysis of compound 1-4. The HPLC analysis revealed that the compounds studied are homogeneous in the environment of 0.2% DMSO up to 96Â hr.View full textDownload full textKeywordsAnti-cancer drugs, benzimidazole, HPLC, hypoxia, nitobenziyidazole, RP-8Related var addthis_config = { ui_cobrand: "Taylor & Francis Online", services_compact: "citeulike,netvibes,twitter,technorati,delicious,linkedin,facebook,stumbleupon,digg,google,more", pubid: "ra-4dff56cd6bb1830b" }; Add to shortlist Link Permalink http://dx.doi.org/10.1080/10826076.2011.582211