Direct laser writing-mediated generation of standardized topographies for dental implant surface optimization

摘要

The functionalization of dental implants, aiming at the improvement of long-term acceptance, is ofnpivotal interest in dental research. Bone, connective tissue, and oral epithelium are in direct contactnto the implant surface and exhibit distinct requirements for proper growth and differentiation. Thenauthors applied direct laser writing and atomic layer deposition for the generation of TiO2-coatednmicro and nanostructures which were subsequently tested for colonization and growth behavior ofnSaOs-2 cells, an osteosarcoma cell line revealing osteoblastic properties. Structures composed ofnrigid posts and flexible rods provide a matrix, which—when spaced adequately—favor the threedimensionalngrowth and proliferation of SaOs-2 cells. The results provide a proof of concept fornthe optimization of dental implant surfaces using generic techniques which deliver highlynstandardized structure motifs supporting the biological functions of the tissues affected