Down-Regulation of GRIM-19 Expression Is Associated With Hyperactivation of STAT3-Induced Gene Expression and Tumor Growth in Human Cervical Cancers

Ying Zhou; Min Li; Ying Wei; Dingqing Feng; Cheng Peng; Haiyan Weng; Yang Ma; Liang Bao; Shreeram Nallar; Sudhakar Kalakonda; Weihua Xiao; Dhananjaya V. Kalvakolanu; Bin Ling

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Down-Regulation of GRIM-19 Expression Is Associated With Hyperactivation of STAT3-Induced Gene Expression and Tumor Growth in Human Cervical Cancers

机译：GRIM-19表达的下调与人类宫颈癌中STAT3诱导的基因表达的过度活化和肿瘤的生长有关。

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*These authors contributed equally to the present study.

机译：* 这些作者对本研究做出了同样的贡献。

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《Journal of Interferon & Cytokine Research》 |2009年第10期|695-704|共10页
作者
Ying Zhou; Min Li; Ying Wei; Dingqing Feng; Cheng Peng; Haiyan Weng; Yang Ma; Liang Bao; Shreeram Nallar; Sudhakar Kalakonda; Weihua Xiao; Dhananjaya V. Kalvakolanu; Bin Ling;
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Anhui Province Key Laboratory of Molecular Medicine and Department of Obstetrics and Gynecology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, People’s Republic of China.;

Anhui Province Key Laboratory of Molecular Medicine and Department of Obstetrics and Gynecology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, People’s Republic of China.;

Anhui Province Key Laboratory of Molecular Medicine and Department of Obstetrics and Gynecology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, People’s Republic of China.;

Anhui Province Key Laboratory of Molecular Medicine and Department of Obstetrics and Gynecology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, People’s Republic of China.;

Anhui Province Key Laboratory of Molecular Medicine and Department of Obstetrics and Gynecology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, People’s Republic of China.;

Department of Pathology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, People’s Republic of China.;

Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China.;

Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China.;

Department of Microbiology and Immunology, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland.;

Department of Microbiology and Immunology, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland.;

Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China.;

Department of Microbiology and Immunology, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland.;

Anhui Province Key Laboratory of Molecular Medicine and Department of Obstetrics and Gynecology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, People’s Republic of China.;

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1. Down-Regulation of GRIM-19 Expression Is Associated With Hyperactivation of STAT3-lncluced Gene Expression and Tumor Growth in Human Cervical Cancers [J] . Ying Zhou, Min Li, Ying Wei Journal of interferon and cytokine research: The official journal of the International Society for Interferon and Cytokine Research . 2009,第10期

机译：GRIM-19表达的下调与人类宫颈癌中STAT3含糊的基因表达和肿瘤生长的过度激活有关。
2. Methylglyoxal suppresses human colon cancer cell lines and tumor growth in a mouse model by impairing glycolytic metabolism of cancer cells associated with down-regulation of c-Myc expression [J] . He Tiantian, Zhou Huaibin, Li Chunmei, Cancer biology & therapy . 2016,第9期

机译：甲基乙二醛通过破坏与c-Myc表达下调相关的癌细胞的糖酵解代谢，从而抑制小鼠结肠癌细胞系和肿瘤模型的生长
3. Vascular endothelial growth factor expression in progression of cervical cancer: correlation with thymidine phosphorylase expression, angiogenesis, tumor cell proliferation, and apoptosis. [J] . Fujiwaki R, Hata K, Iida K, Anticancer Research: International Journal of Cancer Research and Treatment . 2000,第2B期

机译：子宫颈癌进展中的血管内皮生长因子表达：与胸苷磷酸化酶表达，血管生成，肿瘤细胞增殖和凋亡相关。
4. Over-expression of Smac Gene Enhances the Effect ofRadiation Induced Apoptosis in Human Cervical Cancer Cell Line HeLa [C] . ZHAO Baofeng, TIAN Mei, RUAN Jianlei, . 2006

机译：Smac基因的过量表达增强了宫颈癌HeLa细胞辐射诱导的凋亡作用
5. PC cell derived growth factor (PCDGF/granulin precursor) expression, antiestrogen resistance and tumorigenesis in human breast cancer cells. [D] . Tangkeangsirisin, Wisit. 2004

机译：人乳腺癌细胞中PC细胞衍生的生长因子（PCDGF /颗粒蛋白前体）的表达，抗雌激素性和肿瘤发生。
6. Down-Regulation of GRIM-19 Expression Is Associated With Hyperactivation of STAT3-Induced Gene Expression and Tumor Growth in Human Cervical Cancers [O] . Ying Zhou, Min Li, Ying Wei, -1

机译：GRIM-19表达的下调与人类宫颈癌中STAT3诱导的基因表达的过度活化和肿瘤的生长有关。
7. Down-Regulation of GRIM-19 Expression Is Associated With Hyperactivation of STAT3-Induced Gene Expression and Tumor Growth in Human Cervical Cancers [O] . Zhou, Ying, Li, Min, Wei, Ying, 2009

机译：GRIM-19表达的下调与人类宫颈癌中STAT3诱导的基因表达的过度活化和肿瘤的生长有关。

Down-Regulation of GRIM-19 Expression Is Associated With Hyperactivation of STAT3-Induced Gene Expression and Tumor Growth in Human Cervical Cancers

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