Konjac Glucomannan/Poly(vinyl alcohol)/Na~+Rectorite Nanocomposite Films: Structure, Characteristic and Drug Delivery Behaviour

摘要

Konjac glucomannan(KGM)/poly(vinyl alco-hol)(PVA)/Na~+ modified rectorite (Na~+REC) nanocomposite films were obtained by using a casting/solvent evaporation method. The structures and microstructures of KGM/PVA/Na~+REC composite films were analyzed by FTIR, XRD, SEM and TEM. A wide variety of material characteristics for the KGM/PVA/Na~+REC composite films were investigated, including the mechanical property, optical transmittance and thermal stability. The results revealed that by adding PVA more well-intercalative/ exfoliated structure of composite film was obtained. As a result, the KGM/PVA/Na~+REC composite film at low Na~+REC and PVA content exhibited an improvement in mechanical properties and thermal stability due to a reinforcement effect. In vitro drug-controlled release studies showed a slower and more continuous release for KGM/ PVA/Na~+REC composite film in comparison with KGM/ Na~+REC composite film.