Low and Maternal-specific Expression of p57~(KIP2) in Hydatidiform Mole and Its Clinical Implication

摘要

In situ hybridization was applied to locate and detect the expression of p57~(KIP2) in hydatidiform mole (5 cases of partial hydatidiform mole and 18 cases of complete hydatidiform mole) and normal villi (23 cases). The positive signals of p57~(KIP2) expression were analyzed by HPIAS-1000 Image-Analysis System. p57~(KIP2) was highly expressed in normal villi but showed distinct low expression in hydatidiform mole (P<0. 01). Furthermore, the locus of low expression of p57~(KIP2) accorded with the place where lesion of trophoblast occurred. Detection of p57~(KIP2) made it possible to study the genetics of hydatidiform mole at the transcriptional level. Low expression of p57~(KIP2) could be a molecular marker in hydatidiform mole and a target for therapy.