Prenatal perfluoroalkyl substance exposure and neuropsychological development throughout childhood: The INMA Project

摘要

Background: Perfluoroalkyl substances (PFASs) have been related to neurodevelopmental toxicity in animals. However, human studies are inconclusive. Objectives: To evaluate the association between prenatal PFAS exposure and neuropsychological development during childhood. Methods: 1240 mother & ndash;child pairs from the Spanish INMA Project were analyzed. Perfluorohexanesulfonic acid (PFHxS), perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), and perfluorononanoic acid (PFNA) were measured in first-trimester maternal plasma. Neuropsychological development was assessed at 14 months, 4 & ndash;5 and 7 years covering four domains: general cognitive, general motor, attention, and working memory. Associations were studied by means of multivariable regression analyses. Results: PFHxS, PFOA, PFOS, and PFNA medians were: 0.6, 2.4, 6.1, and 0.7 ng/mL. Higher PFAS prenatal exposure was associated with worse motor development at 14 months, especially in the case of PFHxS (beta[95% CI]: - 1.49[-2.73,-0.24]) and to a lesser extent PFOS (- 1.25[-2.62, 0.12]). There was also a marginal positive association between general cognitive development at 4 & ndash;5 years and PFOS (1.17[-0.10, 2.43]) and PFNA (0.99 [-0.13, 2.12]). No clear associations for other neuropsychological outcomes or any sex differences were found. Discussion: This study shows no clear-cut evidence of an association between prenatal PFAS exposure and adverse neuropsychological development in children up to the age of 7 years.