Impact of KIT and PDGFRA Gene Mutations on Prognosis of Patients with Gastrointestinal Stromal Tumors After Complete Primary Tumor Resection

Ying-Yong Hou; Florian Grabellus; Frank Weber; Yang Zhou; Yun-Shan Tan; Jun Li; Kun-Tang Shen; Jin Qin; Yi-Hong Sun; Xin-Yu Qin; Maximillian Bockhorn; Guido Gerken; Christoph E. Broelsch; Andrea Frilling

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Impact of KIT and PDGFRA Gene Mutations on Prognosis of Patients with Gastrointestinal Stromal Tumors After Complete Primary Tumor Resection

机译：完全原发肿瘤切除后KIT和PDGFRA基因突变对胃肠道间质瘤患者预后的影响

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摘要

To investigate the impact of KIT and PDGFRA gene mutations on the prognosis of gastrointestinal stromal tumors (GIST).

机译：研究KIT和PDGFRA基因突变对胃肠道间质瘤（GIST）预后的影响。

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来源
《Journal of Gastrointestinal Surgery 》 |2009年第9期| 1583-1592| 共10页
作者
Ying-Yong Hou; Florian Grabellus; Frank Weber; Yang Zhou; Yun-Shan Tan; Jun Li; Kun-Tang Shen; Jin Qin; Yi-Hong Sun; Xin-Yu Qin; Maximillian Bockhorn; Guido Gerken; Christoph E. Broelsch; Andrea Frilling;
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作者单位

Department of General Visceral and Transplantation Surgery University Hospital Essen Hufelandstr. 55 45122 Essen Germany;

Institute of Pathology and Neuropathology University Hospital Essen Essen Germany;

Department of General Visceral and Transplantation Surgery University Hospital Essen Hufelandstr. 55 45122 Essen Germany;

Department of Pathology Zhongshan Hospital Fudan University Shanghai China;

Department of Pathology Zhongshan Hospital Fudan University Shanghai China;

Department of General Visceral and Transplantation Surgery University Hospital Essen Hufelandstr. 55 45122 Essen Germany;

Department of General Surgery Zhongshan Hospital Fudan University Shanghai China;

Department of General Surgery Zhongshan Hospital Fudan University Shanghai China;

Department of General Surgery Zhongshan Hospital Fudan University Shanghai China;

Department of General Surgery Zhongshan Hospital Fudan University Shanghai China;

Department of General Visceral and Transplantation Surgery University Hospital Essen Hufelandstr. 55 45122 Essen Germany;

Department of Gastroenterology and Hepatology University Hospital Essen Essen Germany;

Department of General Visceral and Transplantation Surgery University Hospital Essen Hufelandstr. 55 45122 Essen Germany;

Department of General Visceral and Transplantation Surgery University Hospital Essen Hufelandstr. 55 45122 Essen Germany;

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原文格式 PDF
正文语种 eng
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关键词
KIT; PDGFRA; Gene mutation; Gastrointestinal stromal tumors;

机译：试剂盒;PDGFRA;基因突变;胃肠道间质瘤;

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专利

1. Impact of KIT and PDGFRA gene mutations on prognosis of patients with gastrointestinal stromal tumors after complete primary tumor resection. [J] . Hou YY, Grabellus F, Weber F, Journal of gastrointestinal surgery: official journal of the Society for Surgery of the Alimentary Tract . 2009 ,第9期

机译：完全原发肿瘤切除后KIT和PDGFRA基因突变对胃肠道间质瘤患者预后的影响。
2. Mutational status of KIT and PDGFRA and expression of PDGFRA are not associated with prognosis after curative resection of primary gastrointestinal stromal tumors (GISTs). [J] . Kern A, Gorgens H, Dittert DD, Journal of Surgical Oncology . 2011 ,第1期

机译：根治性原发性胃肠道间质瘤（GIST）切除后，KIT和PDGFRA的突变状态以及PDGFRA的表达与预后无关。
3. Gastrointestinal stromal tumors - Summary of mutational status of the primary/secondary KIT/PDGFRA mutations, BRAF mutations and SDH defects [J] . Alena Kalfusova, Zdenek Linke, Marketa Kalinova, Pathology Research and Practice . 2019 ,第12期

机译：胃肠道基质肿瘤 - 初级/次级试剂盒/ PDGFRA突变，BRAF突变和SDH缺陷的突变状态概述
4. Malignancy Prediction of Gastrointestinal Stromal Tumors by Evaluating Tumor Vessel Density from Enhanced Spiral CT Scan [C] . Jintao Li, Cihu Yu, Chang Li, International Conference on Communications, Information Management and Network Security . 2019

机译：通过增强螺旋CT扫描评价肿瘤血管密度的恶性肿瘤性质肿瘤
5. Roles of insulin-like growth factor binding protein-3 in gastrointestinal stromal tumors. [D] . Dupart, Jheri J. 2009

机译：胰岛素样生长因子结合蛋白3在胃肠道间质瘤中的作用。
6. Intratumoral KIT mutational heterogeneity and recurrent KIT/ PDGFRA mutations in KIT/PDGFRA wild-type gastrointestinal stromal tumors [O] . Jing Gao, Jian Li, Yanyan Li, 2016

机译：KIT / PDGFRA野生型胃肠道间质瘤的瘤内KIT突变异质性和复发性KIT / PDGFRA突变
7. Microfluidic Deletion/Insertion Analysis for Rapid Screening of KIT and PDGFRA Mutations in CD117-Positive Gastrointestinal Stromal Tumors: Diagnostic Applications and Report of a New KIT Mutation [O] . Zamò, Alberto, Bertolaso, Anna, Franceschetti, Ilaria, 2007

机译：快速筛选CD117阳性胃肠道间质瘤中KIT和PDGFRA突变的微流控删除/插入分析：一种新的KIT突变的诊断应用和报告。

Impact of KIT and PDGFRA Gene Mutations on Prognosis of Patients with Gastrointestinal Stromal Tumors After Complete Primary Tumor Resection

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