Effectiveness of HSV-tk Suicide Gene Therapy Driven by the Grp78 Stress-Inducible Promoter in Esophagogastric Junction and Gastric Adenocarcinomas

Armen Azatian; Hong Yu; Wande Dai; Fiona I. Schneiders; Natalia K. Botelho; Reginald V. N. Lord

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Effectiveness of HSV-tk Suicide Gene Therapy Driven by the Grp78 Stress-Inducible Promoter in Esophagogastric Junction and Gastric Adenocarcinomas

机译：Grp78应力诱导型启动子驱动的HSV-tk自杀基因治疗在食管胃交界处和胃腺癌中的有效性。

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The thymidine kinase gene of the herpes simplex virus (HSV-tk) is a suicide gene when administrated with the prodrug ganciclovir (GCV). This study investigated the effectiveness of HSV-tk activation as gene therapy for gastroesophageal junction and gastric adenocarcinomas using either the stress-inducible Grp78 promoter or the murine leukemia virus long-terminal repeat (LTR) promoter.

机译：与前药更昔洛韦（GCV）一起给药时，单纯疱疹病毒（HSV-tk）的胸苷激酶基因是自杀基因。这项研究调查了HSV-tk激活作为使用压力诱导型Grp78启动子或鼠白血病病毒长末端重复（LTR）启动子的胃食管连接和胃腺癌基因治疗的有效性。

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来源
《Journal of Gastrointestinal Surgery》 |2009年第6期|1044-1051|共8页
作者
Armen Azatian; Hong Yu; Wande Dai; Fiona I. Schneiders; Natalia K. Botelho; Reginald V. N. Lord;
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作者单位

Department of Surgery University of Southern California Keck School of Medicine Los Angeles CA 90033 USA;

Department of Surgery University of Southern California Keck School of Medicine Los Angeles CA 90033 USA;

Department of Surgery University of Southern California Keck School of Medicine Los Angeles CA 90033 USA;

St. Vincent’s Centre for Applied Medical Research and Department of Surgery St. Vincent’s Hospital University of New South Wales Sydney 2010 Australia;

St. Vincent’s Centre for Applied Medical Research and Department of Surgery St. Vincent’s Hospital University of New South Wales Sydney 2010 Australia;

Department of Surgery University of Southern California Keck School of Medicine Los Angeles CA 90033 USA;

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正文语种 eng
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关键词
Gastroesophageal junction adenocarcinoma; Gastric adenocarcinoma; Gastric neoplasms; Gene therapy; HSV-tk; Grp78;

机译：胃食管连接腺癌;胃腺癌;胃肿瘤;基因治疗;HSV-tk;Grp78;

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专利

1. Effectiveness of HSV-tk suicide gene therapy driven by the Grp78 stress-inducible promoter in esophagogastric junction and gastric adenocarcinomas. [J] . Azatian A, Yu H, Dai W, Journal of gastrointestinal surgery: official journal of the Society for Surgery of the Alimentary Tract . 2009,第6期

机译：由Grp78应激诱导型启动子驱动的HSV-tk自杀基因治疗在食管胃交界处和胃腺癌中的有效性。
2. Study protocol of a randomized phase III trial of comparing preoperative chemoradiation with preoperative chemotherapy in patients with locally advanced gastric cancer or esophagogastric junction adenocarcinoma: PREACT [J] . Xiaowen Liu, Jiejie Jin, Hong Cai, BMC Cancer . 2019,第1期

机译：术后胃癌术前化疗比较术前化学疗法术前化疗的随机阶段III试验的研究方案。术语 - 食管癌腺癌
3. A randomized Phase II trial of systemic chemotherapy with and without trastuzumab followed by surgery in HER2-positive advanced gastric or esophagogastric junction adenocarcinoma with extensive lymph node metastasis: Japan Clinical Oncology Group study JCOG1301 (Trigger Study) [J] . Kataoka Kozo, Tokunaga Masanori, Mizusawa Junki, Japanese journal of clinical oncology. . 2015,第11期

机译：一项有或没有曲妥珠单抗，随后伴有广泛淋巴结转移的HER2阳性晚期胃或食管胃交界处腺癌手术的全身化疗的II期随机试验：日本临床肿瘤学小组研究JCOG1301（触发研究）
4. Clinicopathological findings for adenocarcinoma of the esophagogastric junction [C] . Kubota H, Matsumoto H, Kaida Y, International Gastric Cancer Congress . 2011

机译：食管胃癌腺癌的临床病理学发现
5. Development of a Targeted Adenoviral Vector Expressing HSV-TK for use In Breast Cancer Gene Therapy and Analysis through Positron Emission Tomography. [D] . DeSilva, Alan. 2012

机译：靶向HSV-TK的靶向腺病毒载体的开发，用于通过正电子发射断层扫描术对乳腺癌基因进行治疗和分析。
6. Gene Therapy for Human Lung Adenocarcinoma Using a Suicide Gene Driven by a Lung-Specific Promoter Delivered by JC Virus-Like Particles [O] . Chun-Nun Chao, Mien-Chun Lin, Chiung-Yao Fang, -1

机译：使用由JC病毒样颗粒递送的肺特异性启动子驱动的自杀基因对人肺腺癌进行基因治疗
7. Gene Therapy for Human Lung Adenocarcinoma Using a Suicide Gene Driven by a Lung-Specific Promoter Delivered by JC Virus-Like Particles. [O] . Chun-Nun Chao, Mien-Chun Lin, Chiung-Yao Fang, 2016

机译：使用由JC病毒样颗粒提供的肺特异性启动子驱动的自杀基因对人肺腺癌的基因治疗。

Effectiveness of HSV-tk Suicide Gene Therapy Driven by the Grp78 Stress-Inducible Promoter in Esophagogastric Junction and Gastric Adenocarcinomas

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