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首页> 外文期刊>Journal of food protection >Multilaboratory Validation of a Luminex Micro bead-Based Suspension Array for the Identification of the 11 Most Clinically Relevant Shiga Toxin-Producing Escherichia coli O Serogroups
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Multilaboratory Validation of a Luminex Micro bead-Based Suspension Array for the Identification of the 11 Most Clinically Relevant Shiga Toxin-Producing Escherichia coli O Serogroups

机译：基于Luminex微珠的悬浮阵列的多实验室验证，用于鉴定11种临床上最相关的产志贺毒素的大肠杆菌O血清群

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摘要

Rapid and high-throughput identification and serotyping of Shiga toxin-producing Escherichia coli (STEC) O serogroups is important for detecting, investigating, and controlling STEC infection outbreaks and removing hazardous products from commerce. A Luminex microbead-based suspension array has been developed to identify the 11 most clinically relevant STEC serogroups: O26, O45, O91, O103, O104, O111, O113, O121, O128, O145, and O157. Here we present results of a blinded multilaboratory collaborative study involving 10 participants from nine laboratories using 55 unknown slrains. From the total 495 analyses, two false-positive and three false-negative results were obtained, indicating the assay to be a rapid, high-throughput, and robust method for identifying clinically relevant STEC serogroups.
机译：快速和高通量的志贺毒素生产大肠埃希菌（STEC）O血清群的鉴定和血清分型对于检测，调查和控制STEC感染暴发以及从商业中移除危险产品非常重要。已经开发出基于Luminex微珠的悬浮液阵列，以鉴定11种临床上最相关的STEC血清群：O26，O45，O91，O103，O104，O111，O113，O121，O128，O145和O157。在这里，我们介绍了一项盲的多实验室合作研究的结果，该研究涉及来自9个实验室的10名参与者，使用了55种未知的斜线。从总共495次分析中，获得了2个假阳性和3个假阴性结果，表明该测定是一种快速，高通量且鲁棒的方法，可用于识别临床相关的STEC血清群。

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  • 来源
    《Journal of food protection》 |2013年第5期|867-870|共4页
  • 作者

    ANDREW LIN; JULIE A. KASE; MICHELLE M. MOORE; INSOOK SON; NELLY TRAN; LAURIE M. CLOTILDE; KAREN JARVIS; KELLY JONES; KUPPUSWAMY KASTURI; KHAMPHET NABE; MELISSA NUCCI; GAIL S. WAGLEY; FEI WANG; BEILEI GE; THOMAS S. HAMMACK;

  • 作者单位

    U.S. Food and Drug Administration, San Francisco District, Alameda, California 94502;

    U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, College Park, Maryland 20740;

    U.S. Food and Drug Administration, Pacific Regional Laboratory Northwest, Applied Technology Center, Bothell, Washington 98021;

    U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, College Park, Maryland 20740;

    U.S. Food and Drug Administration, Pacific Regional Laboratory Southwest, Irvine, California 92612;

    U.S. Food and Drug Administration, San Francisco District, Alameda, California 94502;

    U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessments, Laurel, Maryland 20708;

    U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Laurel, Maryland 20708;

    U S. Food and Drug Administration, Northeast Regional Laboratory, Jamaica, New York 11433;

    U.S. Food and Drug Administration, Pacific Regional Laboratory-Northwest, Bothell, Washington 98021;

    U.S. Food and Drug Administration, Denver District Laboratory, Lakewood, Colorado 80225;

    U.S. Food and Drug Administration, Southeast Regional Laboratory, Atlanta, Georgia 30309, USA;

    U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Laurel, Maryland 20708;

    U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Laurel, Maryland 20708;

    U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, College Park, Maryland 20740;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
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