Do genetic factors contribute to the association between birth weight and blood pressure?

摘要

Objectives-To evaluate whether genetic factors contribute to the association be- tween low birth weight and increased blood pressure among adolescents. Design-Historical cohort study of twin Pairs. It was evaluated whether (1) a nega- Tive association between birth weight and Systolic blood pressure was found in the Overall twin sample and (2) whether the Intrapair difference in birth weight corre- Lated with the intrapair difference in Systolic blood pressure-thereby control- Ling for the effect of genetic factors (all in Monozygotic and on average half in di- Zygotic pairs).