SIMULTANEOUS LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY DETERMINATION OF SOME PHARMACEUTICALS AND ANTIMICROBIAL DISINFECTANT AGENTS IN SURFACE WATER AND IN URBAN WASTEWATER

摘要

A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneous quantification and confirmation of two diuretics (furosemide, hydrochlorothiazide), five nonsteroidal anti-inflammatory drugs (NSAIDs), (diclofenac, ketoprofen, piroxicam, ibuprofen, naproxen), one fibrate (gemfibrozil) and two antimicrobial agents (triclosan, triclocarban). The compounds were extracted from water samples using Oasis HLB cartridges. The analytes were then identified and quantified using LC-MS/MS with dual-polarity electrospray ionisation in the MRM mode. Good linearity was obtained for all tested compounds (R-2 > 0.99). The limits of detection (LODs) ranged between 0.15 and 24.0 ng l(-1). Spike recoveries ranged from 84 to 115% and from 81 to 117% for urban wastewater and surface water samples, respectively, with satisfactory precision (RSD <20%). Finally, the method was used to analyse real effluent and surface water.