DNA-binding and anti-oxidation properties of binuclear lanthanide(III) complexes of 8-hydroxyquinoline-7-carbaldehyde-(isonicotinyl)hydrazone

摘要

Binuclear complexes [LnL(NO₃)(H₂O)₂]₂ were prepared from the Schiff base 8-hydroxyquinoline-7-carbaldehyde-(isonicotinyl)hydrazone (H₂L) and equivalent molar amounts of Ln(NO₃)_3 · 6H₂O (Ln = La3+, Nd3+, Sm3+, Eu3+, Gd3+, Dy3+, Ho3+, Er3+, Yb3+), respectively. The ligand is dibasic tetradentate and the dimerization occurs through the phenolate oxygen atoms leading to a central four-membered (LnO)₂-ring. The ligand and all the Ln(III) complexes can bind to calf thymus DNA through intercalation with binding constants of 105-106 (mol L−1)−1, and they show strong scavenging abilities on hydroxyl radicals and superoxide radicals. The values of SC ₅₀ of Ln(III) complexes for HO• and are 2.344−13.33 and 4.459−28.48 µmol L−1, respectively. Ln(III) complexes present stronger binding abilities to DNA and stronger anti-oxidation properties than ligand. Complex containing hydroxyl unit shows stronger scavenging abilities on hydroxyl radical, while complex containing N-heteroaromatic substituent shows stronger scavenging abilities on superoxide radicals. Furthermore, earlier rare metal complexes show stronger scavenging abilities on both hydroxyl radicals and superoxide radicals.View full textDownload full textKeywords8-Hydroxyquinoline-7-carbaldehyde, Schiff-base ligand, Lanthanide(III) complexes, Calf thymus DNA, Intercalation, Anti-oxidation propertiesRelated var addthis_config = { ui_cobrand: "Taylor & Francis Online", services_compact: "citeulike,netvibes,twitter,technorati,delicious,linkedin,facebook,stumbleupon,digg,google,more", pubid: "ra-4dff56cd6bb1830b" }; Add to shortlist Link Permalink http://dx.doi.org/10.1080/00958972.2012.683485