Presence of Epstein-Barr virus in lymphoepithelioma-like carcinoma of the middle ear

摘要

Conclusions-EBV associated carcinoma with the morphology f lymphoepithe- lioma can also arise from the middle ear. Aim-To examine the association of Epstein-Barr virus (EBV) with carcinoma Of the ear. Methods-Five non-keratinising squamous cell carcinomas and two undifferentiated carcinomas of the ear were examined. In situ hybridisation was used to localised EBV-encoded RNAs (EBER). Immunohis- Tochemical methods to detect LMP-1 and EBNA2 were performed in the EBER posi- Tive cases. Results -Two cases were EBER positive, Including one non-keratinising and one Undifferentiated carcinoma. Both showed Identical morphology to those arising From the nasopharynx, with abundant Lymphoid stroma. They were both nega- Tive for LMP-1 and EBNA2.