Variability of immunoshitochemical reactivity on stored paraffin slides

摘要

Conclusions-To immnohistochemical de- tection of some antigens located either in the nucleus, in the cytoplasm or on the cytoplasmic membrane could be impaired by storage of paraffin slides as short a time as three months. One should be cau- tions of doing retrospective immunohisto- chemical studies on stored unstained slides. Aims-To investigate the effects of slide Storage on immunohistochemical stain- Ing, since recent reports have indicated That storage of unstained paraffin slides For up to 12 weeks may lead to false nega- Tive immunostaining of tumour markers.