Protective Effect of Tetrandrine and Fructose-1,6-diphos-phate on the Model of Focal Cerebral Ischemia in Rats

摘要

The effect of tetrandrine (Tet) on the infarction area and volume of rat brain induced by middle cerebral artery occlusion (MCAO) was investigated. The treatment with Tet 7.5, 12.0 or 15.0 mg · kg~(-1), or with fructose-1,6-diphosphate (FDP) 200 and 350 mg · kg~(-1) ip immediately after MCAO, respectively, significantly reduced the infarction area and volume in a dose-dependent manner. MK801 and FDP also displayed a protective effect on brain ischemia. A combination of Tet and FDP administered immediately after MCAO, produced a more potent protective effect than those treated with Tet or FDP alone. When Tet or FDP was administered 1 h and 2 h after MCAO, respectively, they could still significantly reduce the infarction area and volume of brain tissue. But, there was no significant protective effect when these two compounds were given 3 h after MCAO.