The Therapeutic Effect of Multiglycosides of Tripterygium wilfordii Hook f. On Autoimmune Syndrome Induced by Campylobacter Jejuni In Mice

摘要

The effect of multiglycosides of Tripterygium wilfordii Hook f. (GTW) on autoimmune syndrome (AIS) was studied. Campylobacter fetus ssp jejuni (CF-1) 3.6×10~9 CFU.mL~-1 was injected intradermally on d_o to induce AIS. GTW 75 and 150 mg.kg~-1.d~-1 were given ig to mice from d_14 to d_28. Four weeks later, hind paw swelling of mice, serum anti-dsDNA antibody, serum anti-SRBC antibody, spleen lymphocyte proliferation were tested and IL-1 and TNF-α produced from macrophages were evaluated.