Pulmonary Delivery of Insulin: Absorption Enhancement of Insulin by Various Absorption Promoters in Rats

摘要

The effects of absorption promoters on the pulmonary absorption of insulin were examined by intratracheal administration of insulin solution in rats. The absorption of insulin from the lung was evaluated by its pharmacological bioavailability (PA/100). Results revealed that the coadministriation of insulin with 20 mmol.L~-1 sodium chalet (PA/100=69.1/100), 1/100 sodium coprolite PA/100=40.4/100), 1/100 Brij 35 (PA/100=46.4/100), 1/100 Brij 78 (PA/100=53.6/100) or GdCl_3 (PA/100=32.2/100 at 0.04 mg.kg~-1 and 36.3/100 at 0.2 mg.kg~-1) (lanthanide compound) induced a significantly greater decline in blood glucose elves, while coadministration of insulin with adjunvants such as 1/100 EDTA (PA/100=19.1/100), 5/100 oleic acid (PA/100=20.8/100) or LuCl_3 (PA/10025.1/100 at 0.2 mg.kg~-1)(lanthanide compound appeared to have no enhancement effect. These observations indicated that the use of proper absorption promoters would be useful for improving the pulmonary absorption of insulin.