N-nitro-L-arginine Attenuates Morphine and Dihydroetorphine-induced Place Preference in Mice

摘要

Opiate dependence has become one of the most urgent problems of modern society. Opiate dependence involves physical and psychical dependence. Although many addicts can be detoxified, the relapse ratio of 95% in 5 a demonstrates that opiate psychical dependence is a problem more troublesome. It has been reported that acute and chronic administration of L- NNA can markedly retard the development of tolerance to physical dependence on morphine, and suppress the abstinence syndromes precipitated by naloxone in opiate dependent rodents, and even reverse the existing morphine tolerance. However, the effect of L-NNA on the positive reinforcement of psychically active substances and its possible mechanism have not yet been reported. In present study, the effect of L- NNA en the psychical dependence induced by opiates was evaluated on the basis of conditioned place preference.