2-cyanoacetamide in the synthesis of heterocyclic compounds: Synthesis of new polysubstituted pyrazole, pyridine and pyrimidine derivatives

摘要

Phenylmethylenecyanoacetamide (1) was successfully transferred into polysubstituted pyrazole, pyridine and pyrimidine derivatives in a one-pot reaction step. Hydrazine hydrate (2a,b), cyanoacetamide (6a), cyanothioacetamide (6b), cyanoacetic acid hydrazide (6c), thiosemicarbazide (10), urea (14a), thiourea (14b) and 2-phenylenediamine (24) were selected as amine nucleophile reagents.