Liquid-Phase Synthesis of 2-Methyl-2-aryloxypropanoic Acid Derivatives from Poly(ethylene glycol) Supported 2-Bromo-2-methylpropanoate

摘要

An efficient liquid-phase synthesis of 2-methyl-2-aryloxypropanoic acid derivatives with good yields and high purity on soluble polyethylene glycol (PEG) has been developed by treatment of PEG-bound 2-bromo-2-methylpropanoate with phenoxides in the presence of a catalytic amount of NBu_4I and KI, and subsequent cleavage from the PEG.