Comparing whole body 18F-2-deoxyglucose positron emission tomography and technetium-99m methylene diphosphate bone scan to detect bone metastases in patients with renal cell carcinomas – a preliminary report

摘要

Purpose: Conventional technetium-99m methylenendiphosphate whole body bone scan (bone scan) hasna high sensitivity but a poor specificity to detect bonenmetastases.However, positron emission tomography withn18F-2-deoxyglucose (FDG-PET) can offer superiornspatial resolution and improved specificity. We havenattempted to evaluate the usefulness of FDG-PET forndetecting bone metastases in renal cell carcinomas (RCC)nandtocompareFDG-PETresults with bone scanfindings.nMethods: Eighteen patients were selected for this studynwith biopsy-proven RCC. They were suspected of havingnbone metastases and were undergoing bone scan andnFDG-PET todetec t bone metastases. The final diagnosesnof bone metastases were established by operative, histopathologicalnfindings or clinical follow-up longer thann1 year by additional radiographs or following FDG-PETbone scan findings showing progressive and extensivenwidespread bone lesions. Results: A total of 52 bonenlesions including 40 metastatic and 12 benign bone lesionsnfound on either FDG-PET or bone scan were evaluated.nFDG-PETcouldaccurately diagnose all 40 metastatic andn12 benign bone lesions. Bone scan could accurately diagnoseonly31metastaticbonenlesions.Diagnostic sensitivitynand accuracy of FDG-PET were 100% and 100%,nrespectively, and bone scan were 77.5% and 59.6%,nrespectively. Conclusions: Our data suggest that FDGPEThasahighernsensitivityandabetter accuracy than thatnof bone scan to detect bone metastases in patients withnRCC.