Prenatal detection of aneuploidies using fluorescence in situ hybridizaiton: A preliminary experience in an Indian set up

摘要

Fluorescence in situ hybridization (FISH) is a powerful molecular cytogenetic technique which allows rapid detection of aneuploidies on interphase cells and metaphase spreads. The aim of the present study was to evaluate FISH as a tool in prenatal diagnosis of aneuploidies in high risk pregnancies in an Indian set up. Prenatal diagnosis was carried out in 88 high-risk pregnancies using FISH and cytogenetic analysis. Multicolour Commercially available FISH probes specific for chromosomes 13, 18, 21, X and Y were used.