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Motion of polymerized albumin particles in a model arteriole in the presence of red blood cells

机译:存在红细胞时模型小动脉中聚合白蛋白颗粒的运动

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摘要

Polymerized albumin particles (poly Alb) with recombinant glycoprotein Ibα (rGPIbα-poly Alb) are a promising candidate for a platelet substitute. Thus, we focused on the lateral motion of poly Alb in the presence of red blood cells, because the lateral motion plays an important role in aggregate formation. We visualized the microscopic motion of poly Alb toward the immobilized ligand (von Willebrand factor, VWF) surface in a model arteriole with red blood cells with a high-speed camera. At a higher shear rate of 1,500 s?1, the concentration profile of poly Alb appeared to peak near the wall. This profile enhances the interaction between the particles and wall. Particularly the migration angle, being the angle of the poly Alb velocity vector, was enlarged near the wall and contributed to transfer of poly Alb toward the immobilized VWF surface. This tendency is desirable to achieve the adhesion of particles on the wall.
机译:具有重组糖蛋白Ibα(rGPIbα-polyAlb)的聚合白蛋白颗粒(poly Alb)是血小板替代品的有希望的候选者。因此,我们将注意力集中在存在红细胞的聚Alb的横向运动上,因为横向运动在聚集体形成中起着重要作用。我们用高速相机在带有红细胞的模型小动脉中观察了聚Alb朝固定化配体(von Willebrand因子,VWF)表面的微观运动。在1,500 s?1 的较高剪切速率下,聚Alb的浓度分布似乎在壁附近达到峰值。该轮廓增强了颗粒与壁之间的相互作用。特别地,迁移角,即聚Alb速度矢量的角度,在壁附近增大,并且有助于聚Alb向固定的VWF表面转移。这种趋势是理想的,以实现颗粒在壁上的粘附。

著录项

  • 来源
    《Journal of Biorheology》 |2009年第1期|29-34|共6页
  • 作者单位

    Department of System Design Engineering Keio University 3-14-1 Hiyoshi Kohoku-Ku Yokohama 223-8522 Japan;

    Department of Polymer Chemistry Waseda University 3-4-1 Ohkubo Shinjyuku-ku Tokyo 169-8555 Japan;

    Department of Polymer Chemistry Waseda University 3-4-1 Ohkubo Shinjyuku-ku Tokyo 169-8555 Japan;

    Department of Biological Engineering MIT Cambridge MA USA;

    School of Medicine Keio University 35 Shinanomachi Shinjyuku-ku Tokyo 160-8582 Japan;

    Department of System Design Engineering Keio University 3-14-1 Hiyoshi Kohoku-Ku Yokohama 223-8522 Japan;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Platelet substitute; Von Willebrand factor; Polymerized albumin particles; Lateral motion;

    机译:血小板替代;冯·威勒布兰德因子;聚合白蛋白颗粒;横向运动;

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