Dietary bovine lactoferricin improved gut microflora, benefited intestinal mucosal morphology and inhibited circular cytokines delivery in 21-day weaned piglets

摘要

To study the effect of feeding pharmacological level of bovine lactoferricin (LFcin), 20 weaned piglets (5.29±0.19 kg) were randomly assigned to four treatment groups and fed a maize-soyabean meal diet containing either no addition (C), 100 mg/kg of cipB (C + B), 100 mg/kg of cipB-LFcin (C + L) or 100 mg/kg of colistin sulphate (C + CS) for 3 weeks. Compared with C and C + B, dietary LFcin reduced faecal score (P 0.05), decreased the concentration of Escherichia coli in the duodenum, jejunum and ileum (P 0.05), increased the concentration of lactobacillus and bifidobacterium in the duodenum, jejunum and ileum (P 0.05), and promoted development of the villus-crypt architecture of the jejunum and ileum. Dietary supplementation with LFcin decreased serum levels of cytokines (interleukin-1,6 [IL-1,6], tumour necrosis factor-α [TNF-α]) (P0.05) and glucagon (P0.05), and increased growth hormone (P0.05). Thus LFcin could relieve the weanling stress in 21-day weaned piglets.View full textDownload full textKeywordsbovine lactoferricin, weaned piglets, gut microflora, circulating cytokines, intestinal mucosal morphologyRelated var addthis_config = { ui_cobrand: "Taylor & Francis Online", services_compact: "citeulike,netvibes,twitter,technorati,delicious,linkedin,facebook,stumbleupon,digg,google,more", pubid: "ra-4dff56cd6bb1830b" }; Add to shortlist Link Permalink http://dx.doi.org/10.1080/09712119.2011.565570