HIV-1 resistance patterns to integrase inhibitors in antiretroviral-experienced patients with virological failure on raltegravir-containing regimens

Daniel da Silva; Liesbeth Van Wesenbeeck; Dominique Breilh; Sandrine Reigadas; Guerric Anies; Kurt Van Baelen; Philippe Morlat; Didier Neau; Michel Dupon; Linda Wittkop; Hervé Fleury

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HIV-1 resistance patterns to integrase inhibitors in antiretroviral-experienced patients with virological failure on raltegravir-containing regimens

机译：抗逆转录病毒经验丰富的患者在接受含raltegravir方案的病毒学治疗后，对整合酶抑制剂的HIV-1抵抗方式

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Background Our aim was to study the in vivo viral genetic pathways for resistance to raltegravir, in antiretroviral-experienced patients with virological failure (VF) on raltegravir-containing regimens.

机译：背景我们的目的是研究在抗逆转录病毒药物治疗中具有病毒学失败（VF）且接受含raltegravir方案的患者中对raltegravir耐药的体内病毒遗传途径。

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《Journal of Antimicrobial Chemotherapy》 |2010年第6期|p.1262-1269|共8页
作者
Daniel da Silva; Liesbeth Van Wesenbeeck; Dominique Breilh; Sandrine Reigadas; Guerric Anies; Kurt Van Baelen; Philippe Morlat; Didier Neau; Michel Dupon; Linda Wittkop; Hervé Fleury;
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作者单位

Laboratoire de Virologie, Bordeaux University Hospital, Bordeaux, France|EA2968, Université Victor Segalen, Bordeaux, France;

Virco BVBA, Mechelen, Belgium;

Laboratoire de Pharmacocinétique, Bordeaux University Hospital, Bordeaux, France;

Laboratoire de Virologie, Bordeaux University Hospital, Bordeaux, France|EA2968, Université Victor Segalen, Bordeaux, France;

Laboratoire de Virologie, Bordeaux University Hospital, Bordeaux, France|EA2968, Université Victor Segalen, Bordeaux, France;

Virco BVBA, Mechelen, Belgium;

Département des Maladies Infectieuses, Bordeaux University Hospital, Bordeaux, France;

Département des Maladies Infectieuses, Bordeaux University Hospital, Bordeaux, France;

Département des Maladies Infectieuses, Bordeaux University Hospital, Bordeaux, France;

INSERM U897 Epidemiology and Biostatistics, ISPED, Bordeaux School of Public Health, University Victor Segalen Bordeaux 2,;

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1. HIV-1 resistance patterns to integrase inhibitors in antiretroviral-experienced patients with virological failure on raltegravir-containing regimens. [J] . da Silva D, Van Wesenbeeck L, Breilh D, The Journal of Antimicrobial Chemotherapy . 2010,第6期

机译：HIV-1对整合酶抑制剂的抗药性模式，在接受抗逆转录病毒治疗的患者中发生了病毒性失败，该患者接受了包含raltegravir方案的病毒学治疗。
2. Adherence and Preexisting Major Protease Inhibitor Resistance Mutations are Associated with Virologic Failure of a Dual-Class Antiretroviral Regimen with Inhibitors of HIV-1 Viral Protease and Integrase [J] . Edward M. Gardner, Andre G. Melendez, Maria Astiz, Journal of the International Association of Providers of AIDS Care. . 2012,第1期

机译：粘附和预先存在的主要蛋白酶抑制剂抗性突变与HIV-1病毒蛋白酶和整合酶抑制剂的双重类抗逆转录病毒疗法的病毒学失败有关。
3. A phase IV randomised, open-label pilot study to evaluate switching from protease-inhibitor based regimen to Bictegravir/Emtricitabine/Tenofovir Alafenamide single tablet regimen in Integrase inhibitor-na?ve, virologically suppressed HIV-1 infected adults harbouring drug resistance mutations (PIBIK study): study protocol for a randomised trial [J] . Collins C. Iwuji, Duncan Churchill, Stephen Bremner, BMC Infectious Diseases . 2020,第1期

机译：IV阶段随机开放标签试验研究，以评估从基于蛋白酶抑制剂的方案转换为Bictegravir / Emtrickabine / Tenofovir alafenainide单片中的整体酶抑制剂-Na've，病毒学抑制的HIV-1感染的成年人患有耐药性突变（Pibik研究）：随机试验的研究方案
4. Improving the Feature Selection for the Development of Linear Model for Discovery of HIV-1 Integrase Inhibitors [C] . Matineh Kashani Moghaddam, Richard Adrian Galvan, Ahmad Reza Hadaegh International Conference on Advances in Big Data Analytics . 2015

机译：改进HIV-1整合酶抑制剂发现线性模型的特征选择
5. Characterization of HIV-1 Integrase Strand Transfer Inhibitor (INSTI)-Enzyme Interactions Towards Long- Term Strategies to Suppress Viremia, Mitigate Antiretroviral Resistance and Prevent Transmission at a Population-Level [D] . ?Osman, Nathan 2020

机译：HIV-1整合酶链转移抑制剂（Insti） - 酶相互作用对抑制病毒血症的长期策略，减轻抗逆转录病毒抗性，防止人口水平传播
6. HIV-1 resistance patterns to integrase inhibitors in Chilean patients with virological failure on raltegravir-containing regimens [O] . Pablo Ferrer, Consuelo Rodriguez, Alicia Sciaraffia, 2020

机译：HIV-1抗性抑制含有含有Raltegravir方案的智利病毒衰竭的抑制剂的抗性模式
7. HIV-1 resistance patterns to integrase inhibitors in antiretroviral-experienced patients with virological failure on raltegravir-containing regimens [O] . D. da Silva, L. Van Wesenbeeck, D. Breilh, 2010

机译：HIV-1抗性抑制剂在抗逆转录病毒的患者中整合到含有病毒病毒失败的抑制剂的抗性模式

HIV-1 resistance patterns to integrase inhibitors in antiretroviral-experienced patients with virological failure on raltegravir-containing regimens

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