CASSETTE genetic constructs expressing TWO BIOLOGICAL ACTIVE SIPHK, effective attacks transcript of HIV-1 subtype A PATIENTS IN RUSSIA TO REVERSE MPHK transcriptase and integrase, and one SIPHK, AIMED AT MPHK CCR5 gene

摘要

Cassette genetic construct anti-HIV-1R-anti-HIV-3R-anti-CCR5-8 based vector GeneClip-U1-neo, containing the insert as specified in Table 1, producing three siPHK - reproduction inhibitors of human immunodeficiency virus type 1 subtype a, and the expression of CCR5 human gene - and comprising two fragments of the genome of HIV-1 subtype a, identified in patients in Russia and corresponding to conserved regions of reverse transcriptase and integrase domain and 19 bp region, corresponding to the gene CCR5 (shown in the third line): where lower case letters are shown between the hinge region parts of palindromes, capable of forming double-stranded duplexes.