Application of ICP-MS to the development of metal-based drugs and diagnostic agents: where do we stand?

摘要

Metallodrug development presents one of the 'killer' applications to sustain further progress of ICP-MS which even with its hyphenated, metallomics-directed configurations has long since attained the status of a mature analytical technique. The incremental advance of ICP-MS in the field is codified and critically assessed in this review. Providing thus an update of a previous review article by the author (see A. R. Timerbaev, J. Anal, At. Spectrom., 2014, 29, 1058-1072), it covers the topics of monitoring the drug-biomolecule interactions, studying cellular and tissue distribution, probing the intracellular transformation and profiling active metabolites, all of which benefit from the sensitive and precise determination of drug-comprising metals. Special emphasis is placed on ICP-MS-based methodologies that offer new insights into drug activation and targeting chemistries. Also addressed are demanding issues of ascertaining the cellular response to a drug and performing tissue imaging in a high-resolution and quantitative way.