Transfer of Ganglioside GM3 Oligosaccharide from a Water Soluble Polymer to Ceramide by Ceramide Glycanase. A Novel Approach for the Chemical-Enzymatic Synthesis of Glycosphingolipids

摘要

It has become a popular topic in recent years that cell surface carbohydrates play central roles in many biological recognition processes. Of particular interest to glycobiology and medicinal chemistry is easy, versatile, and practical methodology for the construction of glycoconjugates of higher structural complexity and in a combinatorial fashion.