Influence of Head Group Mismatch on the Miscibility of Phospholipids in the Physiologically-Relevant Fluid Phase: A Nearest-Neighbor Recognition Analysis

摘要

The mixing behavior of phosphoethanolamine (PE)-like and phosphoglyceral (PG)-like lipids have been examined in the fluid bilayer state by use of nearest-neighbor recognition methods [Vigmond, S.J.;Dewa, T,;Regen, S.L.J.Am. Chem. Soc.1995, 117, 7838]. Disulfide-based phospholipid dimmers derived from 1, 2-dimyristoyl-sn- glycerol-3-phosphoethanolamine (DMPE)have been synthesized, containing PE-and PG-like head geoups.