A Prochelator Activated by β-Secretase Inhibits Aβ Aggregation and Suppresses Copper-Induced Reactive Oxygen Species Formation

摘要

Amyloid plaque formation in the brain plays a central role innthe cognitive dysfunction characteristic of Alzheimer’s Diseasen(AD).n1,2nThe plaques are composed primarily of 39 43 amino acidnamyloid-u0001 peptides (Au0001) that are derived by enzymatic cleavagenof the amyloid precursor protein (APP) by u0001- and γ-secretases.n3nThe extracellularly released Au0001 is then able to bind metal ions suchnas copper and zinc, which not only exacerbate plaque formationnbut, in the case of copper, can also contribute to the formation ofnneurotoxic reactive oxygen species (ROS).