Directed Self-Assembly of Dipeptides to Form Ultrathin Hydrogel Membranes

摘要

Abstract: The dipeptide amphiphile Fmoc-Leu-Gly-OH has been induced to self-assemble into thin surface-nsupported hydrogel gel films and gap-spanning hydrogel membranes. The thickness can be closelyncontrolled, giving films/membranes from tens of nanometers to millimeters thick. SEM and TEM havenconfirmed that the dipeptides self-assemble to form fibers, with the membranes resembling a dense “mat”nof entangled fibers. The films and membranes were stable once formed. The films could be reversiblyndried and collapsed, then reswollen to regain the gel structure.