Nontraditional Reactions of Azomethine Ylides: Decarboxylative Three-Component Couplings of α-Amino Acids

摘要

Decarboxylative reactions of -amino acids with carbonylncompounds were first reported in 1862 in what is now known asnthe Strecker degradation.n1nThe intermediacy of azomethine ylidesnwas first suggested by Rizzin2nand later established by Grigg whonprovided detailed insights into the mechanism of dipole formation.n3nInter- and intramolecular [3 2] cycloadditions of azomethine ylidesnare widely used in synthesis.n4,5nHere we report a three-componentndecarboxylative -functionalization of amino acids that involves annew reaction pathway for azomethine ylides.