Potassium Is Critical for the Ni(II)-Responsive DNA-Binding Activity of Escherichia coli NikR

摘要

Nickel ions are used by many organisms but intracellularnconcentrations must be controlled to minimize toxic effects onncellular metabolism.n1–3nThis task often falls to metal-responsiventranscription factors.n4,5nAn example of such a metalloregulator isnEscherichia coli NikR, which influences the uptake of nickel bynrepressing transcription of the nik operon encoding a nickel importernin response to nickel.