Electro-acupuncture on the iNOS of Lumbar Intervertebral Disk Tissues in Rats

摘要

Objective: The present study is to investigate the mechanism of electro-acupuncture in preventing and treating lumbar intervertebral disk displacement. Methods: Seventy-five Sprauge-Dawley rats were used to establish the models of lumbar intervertebral disk displacement by operation, and divided into five groups including electro-acupuncture group, western medicine group, acupuncture plus medicine group, model group and normal control group, then they were treated with corresponding therapeutic method. The expression of inducible nitric oxide synthase (iNOS) mKNA in the lumbar intervertebral disk tissues of rats was detected by RT-PCR. Results: The expression of iNOS mRNA in the lumbar intervertebral disk tissues of rats in model group was compared with that in normal control group, the significant difference was found (P < 0.01); While the expressions of iNOS mRNA in the lumbar intervertebral disk tissues of rats in electro-acupuncture group, western drug group and acupuncture plus medicine group were all inhibited, and compared with the model group, the significant differences were also found (P < 0.01). Conclusion: Electro-acupuncture could inhibit the expression of iNOS mRNA in the lumbar intervertebral disk tissue.