Synthesis and biological evaluation of phospholane and dihydrophosphole analogues of the glutamate receptor agonist AP4

Stuart J. Conway Jacqueline C. Miller Andrew D. Bond Barry P. Clark and David E. Jane

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Synthesis and biological evaluation of phospholane and dihydrophosphole analogues of the glutamate receptor agonist AP4

机译：谷氨酸受体激动剂AP4的膦酸酯和二氢磷酯类似物的合成及生物学评价

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摘要

The syntheses and preliminary pharmacological charac-nterisation of two novel cyclic phosphinic acid-containingnamino acids designed as conformationally restrictednanalogues of the metabotropic glutamate receptor agonistnAP4 (1) are reported.

机译：报道了两种新的含环次膦酸的氨基酸的合成和初步药理学特性，这些氨基酸被设计为代谢型谷氨酸受体激动剂AP4（1）的构象受限的类似物。

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《Journal of the Chemical Society, Perkin Transactions 1 》 |2002年第14期| p.1625-1627| 共3页
作者
Stuart J. Conway Jacqueline C. Miller Andrew D. Bond Barry P. Clark and David E. Jane;
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aDepartment of Pharmacology, School of Medical Sciences, University of Bristol, Bristol,UK BS8 1TD. E-mail: david.jane@bristol.ac.uk, Fax: u000144 117 927 9839,Tel: u000144 117 9287639bDepartment of Chemistry, University of Cambridge, Lensﬁeld Road, Cambridge,UK CB2 1EW cEli Lilly & Co., Erl Wood Manor, Windlesham, Surrey, UK GU20 6PH,;

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Synthesis and biological evaluation of phospholane and dihydrophosphole analogues of the glutamate receptor agonist AP4

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