Biochip: Cellular Analysis by Atomic Force Microscopy Using Dielectrophoretic Manipulation

摘要

Non-uniform AC electric fields generated by interdigitated microelectrode arrays have been used to manipulate and control biological cells by dielectrophoresis. This technique is incorporated on an integrated Biochip platform designed as a nondestructive system for trapping and immobilising living cells into cavities. Using dielectrophoresis-based single particle traps, cells have been directed into cavities aligned between the interdigitated electrodes by both positive and negative dielectrophoresis. The motivation for development of the Biochip is to analyse the cell structure in response to various stimuli by atomic force microscopy.