Bacterial Lipoproteins Differentially Regulate Human Primary and Memory CD4+ T and B Cell Responses to Pneumococcal Protein Antigens through Toll-Like Receptor 2

摘要

Background. Bacterial lipoproteins (BLPs) are expressed across a range of bacteria and are able to activate Toll-like receptor 2 (TLR-2). BLPs enhance immune responses in naive individuals and have therefore been tested as candidate vaccine adjuvants. It is not known whether BLPs affect any preexisting immunity (eg, memory cell response in primed individuals). Colonization with pneumococcus (PNC), which primes for memory cell response, is common in young children.