Enhanced Indoleamine 2,3-Dioxygenase Activity in Patients with Severe Sepsis and Septic Shock

Pierre Tattevin; Delphine Monnier; Olivier Tribut; Joelle Dulong; Nadège Bescher; Frederic Mourcin; Fabrice Uhel; Yves Le Tulzo

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Enhanced Indoleamine 2,3-Dioxygenase Activity in Patients with Severe Sepsis and Septic Shock

机译：严重脓毒症和感染性休克患者中吲哚胺2,3-双加氧酶活性增强

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Background. Severe sepsis results in a sustained deleterious immune dysregulation. Indoleamine 2,3-dioxygenase (IDO), the rate-limiting enzyme of tryptophan catabolism, plays a pivotal role in immune tolerance and is induced during various inflammatory conditions.

机译：背景。严重的败血症导致持续有害的免疫失调。吲哚胺2,3-二加氧酶（IDO）是色氨酸分解代谢的限速酶，在免疫耐受中起关键作用，并在各种炎症条件下被诱导。

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《Journal of Infectious Diseases 》 |2010年第6期| p.956-966| 共11页
作者
Pierre Tattevin; Delphine Monnier; Olivier Tribut; Joelle Dulong; Nadège Bescher; Frederic Mourcin; Fabrice Uhel; Yves Le Tulzo;
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Service des Maladies Infectieuses et Réanimation MédicaleBretagne, Rennes, France|Institut National de la Santé et de la Recherche Médicale (INSERM) U835Bretagne, Rennes, France;

Service d'Immunologie, Thérapie Cellulaire et Hématopoïèse, Pôle Cellules et TissusBretagne, Rennes, France|INSERM U917Bretagne, Rennes, France;

Laboratoire de Pharmacologie Clinique et Expérimentale, Centre Hospitalier UniversitaireBretagne, Rennes, France|Centre d'Investigation Clinique, INSERM 0203, Université Rennes 1, IFR140Bretagne, Rennes, France;

INSERM U917Bretagne, Rennes, France|Etablissement Francais du Sang,Bretagne, Rennes, France;

Laboratoire de Pharmacologie Clinique et Expérimentale, Centre Hospitalier UniversitaireBretagne, Rennes, France;

INSERM U917Bretagne, Rennes, France|Etablissement Francais du Sang,Bretagne, Rennes, France;

Service des Maladies Infectieuses et Réanimation MédicaleBretagne,;

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1. Enhanced indoleamine 2,3-dioxygenase activity in patients with severe sepsis and septic shock. [J] . Tattevin P, Monnier D, Tribut The Journal of Infectious Diseases . 2010 ,第6期

机译：严重败血症和败血性休克患者的吲哚胺2,3-二加氧酶活性增强。
2. Treatment with granulocyte-macrophage colony-stimulating factor is associated with reduced indoleamine 2,3-dioxygenase activity and kynurenine pathway catabolites in patients with severe sepsis and septic shock. [J] . Schefold JC, Zeden JP, Pschowski R, Scandinavian journal of infectious diseases. . 2010 ,第3期

机译：患有严重脓毒症和脓毒性休克的患者，用粒细胞巨噬细胞集落刺激因子治疗可降低吲哚胺2,3-二加氧酶活性和犬尿氨酸途径代谢产物。
3. Outcomes in severe sepsis and patients with septic shock do not matter! PIRO is a score to treat severe septic and septic shock patients not to measure outcomes. [J] . Rubulotta F, Ramsay G Critical care medicine . 2012 ,第2期

机译：严重败血症和败血性休克患者的结局无所谓！ PIRO是治疗严重败血症和败血性休克患者而不评估结局的评分。
4. Relation of heart rate variability to serum levels of C-reactive protein in patients with severe sepsis and septic shock [C] . Papaioannou V.P., Dragoumanis C.D., Pneumatikos I.P. Computers in Cardiology, 2009 . 2009

机译：严重败血症和败血性休克患者心率变异性与血清C反应蛋白水平的关系
5. Utilizing a multi-faceted approach to improve 6-hour bundle compliance of patients with severe sepsis and septic shock [D] . Gabbard, Erika 2015

机译：利用多刻度的方法来改善6小时的患者患者患者的6小时捆绑休克
6. Comparing the effect of hydroxyethyl starch 130/0.4 with balanced crystalloid solution on mortality and kidney failure in patients with severe sepsis (6S - Scandinavian Starch for Severe Sepsis/Septic Shock trial): Study protocol design and rationale for a double-blinded randomised clinical trial [O] . Anders Perner, Nicolai Haase, Jørn Wetterslev, 2011

机译：比较羟乙基淀粉130 / 0.4和平衡的晶体溶液对严重脓毒症患者的死亡率和肾衰竭的影响（6S-斯堪的纳维亚淀粉用于严重脓毒症/败血性休克试验）：双盲随机研究的研究方案设计和原理临床试验
7. Enhanced indoleamine 2,3-dioxygenase activity in patients with severe sepsis and septic shock. [O] . Tattevin, Pierre, Monnier, Delphine, Tribut, Olivier, 2010

机译：严重败血症和败血性休克患者的吲哚胺2,3-二加氧酶活性增强。

Enhanced Indoleamine 2,3-Dioxygenase Activity in Patients with Severe Sepsis and Septic Shock

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