Leukemias

摘要

Leukemias are a heterogeneous group of blood diseases in all age groups. Leukemias have traditionally served as models for tumor diseases. The term was coined in 1847 to report patients with what was later recognized to be chronic myeloid leukemia (CML). The elucidation of CML pathogenesis led to a rationally designed therapy targeted at the cause of the disease. Life expectancy of CML has increased to a median of > 25 years. Advances have been made with molecular characterization and therapy also in the other leukemias. Progress is facilitated by new modes of cooperation, such as the European LeukemiaNet which comprises leukemia study groups and their interdisciplinary partner groups in 33 countries caring for some 10,000 leukemia patients across Europe.