Pharmacovigilance from social media: An improved random subspace method for identifying adverse drug events

摘要

Objective: Recent advances in Web 2.0 technologies have seen significant strides towards utilizing patient-generated content for pharmacovigilance. Social media-based pharmacovigilance has great potential to augment current efforts and provide regulatory authorities with valuable decision aids. Among various pharmacovigilance activities, identifying adverse drug events (ADEs) is very important for patient safety. However, in health-related discussion forums, ADEs may confound with drug indications and beneficial effects, etc. Therefore, the focus of this study is to develop a strategy to identify ADEs from other semantic types, and meanwhile to determine the drug that an ADE is associated with.