Mobile-aided screening system for proliferative diabetic retinopathy

摘要

NeoVascularization (NV) occurs in the Proliferative Diabetic Retinopathy (PDR) stage, where the development progress of new vessels presents a high risk for severe vision loss and blindness. Therefore, early NV detection is primordial to preserve patient's vision. Several automated methods have been proposed to detect the NV on retinograph-captured fundus images. However, their employment is constrained by the reduced ophthalmologist-per-person ratio and the expensive equipment for image capturing.This paper presents a novel method for NV detection in smartphone-captured fundus images. The implementation of the method on a smartphone having an optical lens for fundus capturing leads to a Mobiles-Aided-Screening system of PDR (MAS-PDR). The challenge is to ensure accurate and robust detection even with moderate quality of fundus image, on reduced execution time. Within this objective, we identify the major criteria of neovascularized vessels which are tortuosity, width, bifurcation, and density. Our main contribution consists in proposing a sharp feature to reflect each criterion on reduced computational complexity processing. Therefore, the features are provided to a random forest classifier to deduce the PDR stage.A dataset raised from publicly databases is used on a 10-cross validation process where 98.69% accuracy, 97.73% sensitivity, and 99.12% specificity are achieved. To evaluate the robustness, the same experimentation is repeated after applying motion blur filters to the fundus image dataset, where 98.91% accuracy, 96.75% sensitivity, and 100% specificity are deduced. Moreover, NV screening is performed under 3 s when executed in smartphone devices demonstrating the appropriateness of our method to MAS-PDR.