Daily dose of interferon alpha-2b and ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection: a randomised controlled study

GianPiero Benetti; Mauro Borzio; Giuliano Ramella; Giorgio Bellati; Silvia Fargion; Alberto Colombo; Guido Croce; Carlo Iamoletti; Federico Balzola; Mario Rizzetto

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Daily dose of interferon alpha-2b and ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection: a randomised controlled study

机译：初治慢性丙型肝炎病毒基因型1感染患者中干扰素α-2b和利巴韦林的每日剂量：一项随机对照研究

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The treatment of patients with hepatitis C virus (HCV) genotype 1 infection remains disappointing.

机译：丙型肝炎病毒（HCV）基因型1感染患者的治疗仍然令人失望。

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来源
《Internal and Emergency Medicine》 |2006年第2期|113-118|共6页
作者
GianPiero Benetti; Mauro Borzio; Giuliano Ramella; Giorgio Bellati; Silvia Fargion; Alberto Colombo; Guido Croce; Carlo Iamoletti; Federico Balzola; Mario Rizzetto;
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作者单位

Servizio di Epatologia Divisione di Medicina I Ospedale Predabissi Via Pandina 20077 Vizzolo Predabissi Melegnano (MI) Italy;

Section of Gastroenterology Department of Medicine Fatebenefratelli Hospital Milan Italy;

Servizio di Epatologia Divisione di Medicina I Ospedale Predabissi Via Pandina 20077 Vizzolo Predabissi Melegnano (MI) Italy;

Section of Gastroenterology Department of Medicine S. Anna Hospital Como Italy;

Clinical Medicine 1 Policlinico Hospital University of Milan Milan Italy;

Section of Gastroenterology Department of Medicine S. Anna Hospital Como Italy;

Section of Gastroenterology Division of Medicine San Carlo Borromeo Hospital Milan Italy;

Section of Hepatology Division of Medicine Hospital of Treviglio Treviglio (BG) Italy;

Department of Gastroenterology Le Molinette Hospital University of Turin Turin Italy;

Department of Gastroenterology Le Molinette Hospital University of Turin Turin Italy;

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正文语种 eng
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关键词
chronic hepatitis C; cirrhosis; genotype 1; induction therapy;

机译：慢性丙型肝炎;肝硬化;基因型1;诱导治疗;

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专利

1. Simeprevir plus sofosbuvir, with or without ribavirin, to treat chronic infection with hepatitis C virus genotype 1 in non-responders to pegylated interferon and ribavirin and treatment-naive patients: The COSMOS randomised study [J] . LawitzE., SulkowskiM.S., GhalibR., The Lancet . 2014,第9956期

机译：Simeprevir加sofosbuvir联合利巴韦林或不联合利巴韦林，用于治疗对聚乙二醇化干扰素和利巴韦林无反应的初治患者和初治患者的丙型肝炎病毒基因型1慢性感染：COSMOS随机研究
2. Simeprevir with pegylated interferon alfa 2a or 2b plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-2): a randomised, double-blind, placebo-controlled phase 3 trial (vol 384, pg 414, 2014) [J] . Manns M., Marcellin P., Poordad F. The Lancet . 2016,第10030期

机译：Simeprevir与聚乙二醇干扰素α2a或2b联合利巴韦林在未接受治疗的慢性丙型肝炎病毒基因型1感染患者中（QUEST-2）：一项随机，双盲，安慰剂对照的3期临床试验（第384卷，第414页，2014年））
3. Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-1): a phase 3, randomised, double-blind, placebo-controlled trial (vol 384, pg 403, 2014) [J] . Jacobson I. M., Dore G. J., Foster G. R. The Lancet . 2016,第10030期

机译：Simeprevir与聚乙二醇干扰素α2a联合利巴韦林在未接受治疗的慢性丙型肝炎病毒基因型1感染患者中（QUEST-1）：3期随机，双盲，安慰剂对照试验（第384卷，第403页，2014年）
4. HLA-C gene in Hepatitis C Virus infected Patients in Egypt, to estimate the relation between HLA-C gene and Interferon/Ribavirin as treatment for hepatitis C virus [C] . SHADEN MUAWIA HANAFY, AMAL AHMED ABBAS, SAFY KABEEL ALY MANSOUR International Conference on Cellular and Molecular Biology, Biophysics and Bioengineering . 2015

机译：HLA-C基因在丙型肝炎病毒中感染埃及患者，估计HLA-C基因和干扰素/利巴韦林与丙型肝炎病毒治疗的关系
5. Population pharmacokinetics and efficacy of ribavirin in patients with chronic hepatitis C genotype 1 infection. [D] . Jin, Runyan. 2010

机译：利巴韦林在慢性丙型肝炎基因型1感染患者中的群体药代动力学和功效。
6. A reduced dose of ribavirin does not influence the virologic response during pegylated interferon alpha-2b and ribavirin combination therapy in patients with genotype 1 chronic hepatitis C [O] . Byung Chul You, Young Seok Kim, Hun il Kim, 2012

机译：降低剂量的利巴韦林不会影响聚乙二醇干扰素α-2b和利巴韦林联合治疗基因型1型慢性丙型肝炎患者的病毒学应答
7. Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-1): a phase 3, randomised, double-blind, placebo-controlled trial [O] . JacobsonIR, Dore GJ, FosterGR, 2014

机译：Simeprevir与聚乙二醇干扰素α2a联合利巴韦林在未接受治疗的慢性丙型肝炎病毒基因型1型感染（QUEST-1）的患者中：3期，随机，双盲，安慰剂对照试验

Daily dose of interferon alpha-2b and ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection: a randomised controlled study

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