Hybrid Composite Materials Based on Chitosan and Gelatin and Reinforced with Hydroxyapatite for Tissue Engineering

摘要

Abstract—The fundamentals of the technology are developed for the fabrication of hybrid composite chito-san/gelatin—hydroxyapatite materials aimed for medical applications as porous matrices in regenerating damaged bone tissues, and the properties of the above materials are investigated. They are elastic, having a porosity of up to 90% and pores of up to 700 xm in size; possess controlled dissolution kinetics; contain up to 90 wt % hydroxyapatite or carbonate-substituted hydroxyapatite in the form of nanodisperse powders or granules with a size of up to 500 urn; and are characterized by no cytotoxicity. Their introduction into the site of a bone defect considerably accelerates the process of regeneration in a bone tissue.