Indexing genomic sequence libraries

摘要

This paper describes an extensible, open-source (GPL) data repository and retrieval system that supports fast, efficient, keyword based retrieval of genomic sequences from 1 multiple libraries with retrieved sequences post-processed by FASTA, Smith-Waterman and other analysis software. This application is implemented for Linux and is written in Mumps, C, and C++ with supporting components that include the Berkeley Data Base, the Perl Compatible Regular Expression Library, GLADE, and tools such as FASTA, Smith-Waterman, and modules from EMBOSS. The package described here can quickly index data sets of up to 256 terabytes using a B-tree based multi-dimensional data model. An example is presented that indexes the text of the full NCBI Genbank library. (C) 2003 Elsevier Ltd. All rights reserved.