Shikonin inhibits IgE-mediated histamine release by human basophils and Syk kinase activity

H. Takano-Ohmuro; L. S. Yoshida; Y. Yuda; K. Morioka; S. Kitani

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Shikonin inhibits IgE-mediated histamine release by human basophils and Syk kinase activity

机译：紫草素抑制人嗜碱性粒细胞释放IgE介导的组胺和Syk激酶活性

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摘要

Shikonin, a component of the herbal medicine “Shikon”, is known to suppress inflammatory reactions, but its molecular targets are not identified. This study examines the effect of shikonin on human basophil degranulation response and aims to identify its targets.

机译：紫草素（Shikonin）是草药“ Shikon”的一种成分，已知能够抑制炎症反应，但其分子靶标尚未确定。这项研究检查了紫草素对人嗜碱性粒细胞脱粒反应的影响，旨在确定其靶标。

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来源
《Inflammation Research》 |2008年第10期|484-488|共5页
作者
H. Takano-Ohmuro; L. S. Yoshida; Y. Yuda; K. Morioka; S. Kitani;
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作者单位

Laboratory of Pharmaceutical Information Science Faculty of Pharmacy and Research Institute of Pharmaceutical Sciences Musashino University 1-1-20 Shinmachi Nishitokyo Tokyo 202-8585 Japan;

Laboratory of Pharmaceutical Information Science Faculty of Pharmacy and Research Institute of Pharmaceutical Sciences Musashino University 1-1-20 Shinmachi Nishitokyo Tokyo 202-8585 Japan;

Laboratory of Pharmaceutical Information Science Faculty of Pharmacy and Research Institute of Pharmaceutical Sciences Musashino University 1-1-20 Shinmachi Nishitokyo Tokyo 202-8585 Japan;

The Tokyo Metropolitan Institute of Medical Science 3-18-22 Honkomagome Bunkyo-ku Tokyo 113-8613 Japan;

Health Service Center Tokyo University of Marine Science and Technology 4-5-7 Konan Minato-ku Tokyo 108-8477 Japan;

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原文格式 PDF
正文语种 eng
中图分类
关键词
Shikonin; Syk; Lyn; IgE-mediated histamine release; Human basophils; FcεRI; Off-chip mobility shift assay;

机译：Shikonin;Syk;Lyn;IgE介导的组胺释放;人类嗜碱性粒细胞;FcεRI;芯片外迁移率迁移分析;

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专利

1. Shikonin inhibits IgE-mediated histamine release by human basophils and Syk kinase activity. [J] . Takano Ohmuro H, Yoshida LS, Yuda Y Inflammation research: Official journal of the European Histamine Research Society . 2008,第10期

机译：紫草素抑制人嗜碱性粒细胞释放IgE介导的组胺和Syk激酶活性。
2. Aspirin augments IgE-mediated histamine release from human peripheral basophils via Syk kinase activation [J] . MatsuoH., YokoojiT., MoritaH., Allergology international: official journal of the Japanese Society of Allergology . 2013,第4期

机译：阿司匹林通过Syk激酶激活增强IgE介导的组胺从人外周嗜碱性粒细胞的释放
3. Aspirin Augments IgE-Mediated Histamine Release from Human Peripheral Basophils via Syk Kinase Activation [J] . Hiroaki Matsuo, Tomoharu Yokooji, Hironobu Morita, Allergology international: official journal of the Japanese Society of Allergology . 2013,第4期

机译：阿司匹林通过Syk激酶激活增强了IgE介导的组胺从人周围嗜碱性粒细胞的释放。
4. Vascular Endothelial Growth Factor-A Is Stored in and Immunologically Released from Human Basophils [C] . G. Marone, N. Prevete, I. Fiorentino, Collegium Internationale Allergologicum . 2007

机译：血管内皮生长因子-A储存在人嗜碱性粒细胞中和免疫学上释放
5. Paradoxical GCN2 Kinase Activation Enhances Antitumor Activity of Kinase Inhibitors [D] . Tang, Colin P. 2021

机译：矛盾的GCN2激酶活化可增强激酶抑制剂的抗肿瘤活性
6. Regulation of human basophil activation; the role of Na+ and Ca2+ in IL-3-induced potentiation of IgE-mediated histamine release from human basophils. [O] . F Beauvais, K Echasserieau, C Burtin, 1994

机译：调节人类嗜碱性粒细胞的活化； Na +和Ca2 +在IL-3诱导的IgE介导的组胺从嗜碱性粒细胞释放中的作用。
7. Aspirin Augments IgE-Mediated Histamine Release from Human Peripheral Basophils via Syk Kinase Activation [O] . Hiroaki Matsuo, Tomoharu Yokooji, Hironobu Morita, 2013

机译：阿司匹林通过syk激酶活化增强人外周嗜碱性粒细胞释放IgE介导的组胺

Shikonin inhibits IgE-mediated histamine release by human basophils and Syk kinase activity

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