Pretreatment with anti-flagellin serum delays acute lung injury in rats with sepsis

Ming-Dong Hu; Yu Yang; Chang-Xi Zhou; Qi Li; Wang Yi; Gui-Sheng Qian; Mei Mao; Jian-Cheng Xu

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Pretreatment with anti-flagellin serum delays acute lung injury in rats with sepsis

机译：抗鞭毛蛋白血清预处理可延迟败血症大鼠的急性肺损伤

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摘要

This study examined the reduction of sepsis-induced ALI by inhibition of flagellin-stimulated TLR5 signaling.

机译：这项研究研究了通过抑制鞭毛蛋白刺激的TLR5信号转导减少败血症诱导的ALI。

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来源
《Inflammation Research》 |2012年第8期|p.837-844|共8页
作者
Ming-Dong Hu; Yu Yang; Chang-Xi Zhou; Qi Li; Wang Yi; Gui-Sheng Qian; Mei Mao; Jian-Cheng Xu;
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作者单位

Institute of Respiratory Diseases of PLA, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China;

Institute of Respiratory Diseases of PLA, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China;

Department of Respiratory Medicine, General Hospital of PLA, Beijing, China;

Institute of Respiratory Diseases of PLA, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China;

Institute of Respiratory Diseases of PLA, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China;

Institute of Respiratory Diseases of PLA, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China;

Department of Respiratory Medicine, Wuhan General Hospital of Guangzhou Military Command, Wuhan, 430061, China;

Institute of Respiratory Diseases of PLA, Xinqiao Hospital, Third Military Medical University, Chongqing, 400;

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正文语种 eng
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关键词
Flagellin; Anti-flagellin serum; Sepsis; Acute lung injury; TLR5;

机译：鞭毛蛋白;抗鞭毛蛋白血清;败血症;急性肺损伤;TLR5;

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专利

1. Pretreatment with anti-flagellin serum delays acute lung injury in rats with sepsis [J] . HuM.-D., YangY., ZhouC.-X., Inflammation research: Official journal of the European Histamine Research Society . 2012,第8期

机译：抗鞭毛蛋白血清预处理可延迟败血症大鼠的急性肺损伤
2. Significance of measuring S100A12 and sRAGE in the serum of sepsis patients with postoperative acute lung injury. [J] . Kikkawa T, Sato N, Kojika M, Digestive surgery . 2010,第4期

机译：脓毒症术后急性肺损伤患者血清S100A12和sRAGE检测的意义。
3. High tidal volume mechanical ventilation-induced lung injury in rats is greater after acid instillation than after sepsis-induced acute lung injury, but does not increase systemic inflammation: an experimental study [J] . Jan W Kuiper, Frans B Pl?tz, AB Johan Groeneveld, BMC Anesthesiology . 2011,第1期

机译：实验研究表明，高潮气量的机械通气诱发的大鼠肺损伤在酸滴注后比脓毒症引起的急性肺损伤后更大，但并未增加全身性炎症：
4. Incidence and Clinical Features of Acute Lung Injury/ Adult Respiratory Distress Syndrome Complicating Acute Myocardial Infarction Patients Treated with Primary Angioplasty [C] . Garcia Gonzalez M.J., Juarez Prera R., Blanco Palacios G., International Congress on Coronary Artery Disease . 2009

机译：急性肺损伤/成人呼吸窘迫综合征复杂性急性心肌梗死患者的发病率和临床特征对初级血管成形术治疗的急性心肌梗死患者
5. Hsp-90 inhibitors in sepsis and sepsis-induced acute lung injury [D] . Chatterjee, Anuran 2007

机译：Hsp-90抑制剂在败血症和败血症诱导的急性肺损伤中的作用
6. Acute Lung Injury and Acute Kidney Injury Are Established by Four Hours in Experimental Sepsis and Are Improved with Pre but Not Post Sepsis Administration of TNF-α Antibodies [O] . Rhea Bhargava, Christopher J. Altmann, Ana Andres-Hernando, -1

机译：急性肺损伤和急性肾脏损伤在实验性败血症中建立了四个小时并通过败血症前（而非事后）给予TNF-α抗体改善
7. Acute lung injury and acute kidney injury are established by four hours in experimental sepsis and are improved with pre, but not post, sepsis administration of TNF-α antibodies. [O] . Rhea Bhargava, Christopher J Altmann, Ana Andres-Hernando, 2013

机译：在实验性败血症中建立急性肺损伤和急性肾损伤4小时，并且通过给予TNF-α抗体的脓毒症之前但不是之后改善。
8. Mechanism of Tissue Remodeling in Sepsis-Induced Acute Lung Injury [R] . Roman, J. 2006

机译：脓毒症致急性肺损伤组织重塑机制的研究

Pretreatment with anti-flagellin serum delays acute lung injury in rats with sepsis

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