Bilirubin rebound after intensive phototherapy for neonatal jaundice

摘要

This study was conducted to determine the incidence and magnitude of postphototherapy bilirubin rebound in neonates. Subjects included inborn neonates needing phototherapy for hyperbilirubinemia. Standard guidelines were used to start and stop phototherapy. Rebound bilirubin was measured 24±6 h after stopping phototherapy. Significant bilirubin rebound (SBR) was defined as postphototherapy bilirubin level needing reinstitution of phototherapy. Among 245 neonates with hyperbilirubinemia, post-phototherapy bilirubin estimation was done in 232 neonates. A total of 17 (7.3%) neonates developed SBR. In neonates with SBR, bilirubin increased by 2.3 mg/dL (95% CI 1.6–3.0) after stopping phototherapy. Risk factors for SBR included birth at 35 weeks of gestation (RR 4.3, 95% CI 1.5–12.0), birthweight 2000 g (RR 3.2, 95% CI 1.0–10.3) and onset of jaundice at 60 h of age (RR 3.3, 95% CI 1.2–9.0). Post-phototherapy discharge and follow-up planning should take into account these risk factors.