Structure prediction with FAMS for proteins screened critically to autoimmune diseases based upon bioimformatics

摘要

Drug discovery for autoimmune diseases is recently recognized to be an important task. In this study, we try to perform structure prediction of proteins whose gene promoter regions were preV1ous reported to be specifically methelysed or de-methylased commonly for three autoimmune diseases, systemic lupus erythematosus, rheumatoid arthritis, and dermatomyositis. FAMS were employed for this purpose and we can predict three dimensional structure with significantly small enough P-values. Most of them are suggested to be self immunology related proteins and will be important drug target candidates. We also found some proteins whichform complex with each other. The possibility of a new drug target, i.e., suppression of protein complex formation is suggested.