Design and imaging studies of a position sensitive photomultiplier based dynamic SPECT system

摘要

The design and image reconstruction aspects of dynamic SPECT (single-photon-emission computed tomography) instrumentation utilizing multiple rings of position-sensitive photomultiplier tubes (PSPMTs) are reported. A diverging cone-beam collimator is attached to each PSPMT to achieve a 22-cm-diameter spherical field of view in a system designed for head imaging. The resolution with the diverging collimator is estimated to be approximately 20% worse than with a parallel hold collimator. Iterative and direct cone-beam reconstruction algorithms have been investigated under different conditions of angular sampling and counting statistics. The ramifications of temporal resolution and signal-to-noise ratio are discussed in relation to dynamic SPECT imaging of labeled cisplatin for chemotherapy.